Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cone-rod dystrophy. Phenotypic diversity by retinal function testing.

K Yagasaki1, S G Jacobson

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33101.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extravasation associated with cancer drug therapy: multidisciplinary guideline of the Japanese Society of Cancer Nursing, Japanese Society of Medical Oncology, and Japanese Society of Pharmaceutical Oncology.

ESMO open·2024
Same author

Effect of Dietary Lysine on Endogenous Hyperlipidemia in Nephrotic Rats.

Bioscience, biotechnology, and biochemistry·2016
Same author

Retinal optogenetic therapies: clinical criteria for candidacy.

Clinical genetics·2013
Same author

A novel flow-injection analysis system for evaluation of antioxidants by using sodium dichloroisocyanurate as a source of hypochlorite anion.

Drug discoveries & therapeutics·2012
Same author

Assay systems for screening food components that have anti-proliferative and anti-invasive activity to rat ascites hepatoma cells: In vitro and ex vivo effects of green tea extract.

Cytotechnology·2012
Same author

Inhibitory effect of serum from rats administered with coffee on the proliferation and invasion of rat ascites hepatoma cells.

Cytotechnology·2012
Same journal

The economics of the initial preventive physical examination in medicare-reply.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

Modification of silicone oil retention sutures in aphakic eyes with iris loss-reply;.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

December 2011 archives web quiz winner.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

Angle involvement and glaucoma in patients with biopsy-proven iris melanoma: a response-reply.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

About this journal.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
Same journal

In memoriam: goodwin m. Breinin, MD (1918-2011).

Archives of ophthalmology (Chicago, Ill. : 1960)·2013
See all related articles

This study identified three distinct visual dysfunction patterns in cone-rod dystrophy patients using electroretinography and perimetry. These patterns aid in understanding disease progression and genetic inheritance in retinal degeneration.

Area of Science:

  • Ophthalmology
  • Genetics
  • Neuroscience

Background:

  • Cone-rod dystrophy (CRD) encompasses a group of inherited retinal diseases.
  • Understanding CRD subtypes is crucial for diagnosis and management.
  • Autosomal recessive and simplex CRD forms present with significant visual impairment.

Purpose of the Study:

  • To classify visual dysfunction patterns in autosomal recessive or simplex cone-rod dystrophy.
  • To correlate these patterns with electroretinography and visual field testing.
  • To analyze the progression and familial consistency of identified patterns.

Main Methods:

  • Utilized rod and cone electroretinography (ERG).
  • Employed light- and dark-adapted static threshold perimetry.

Related Experiment Videos

  • Analyzed visual field defects and fixation stability.

    • Main Results:

    • Identified three distinct patterns of visual dysfunction.
    • Pattern 1: Central scotoma, eccentric fixation, mild peripheral dysfunction, slow progression.
    • Pattern 2: More severe, central scotoma, eccentric fixation, greater cone ERG loss, peripheral field loss precedes midperipheral.
    • Pattern 3: Rapidly progressive, unsteady fixation, no measurable cone function, retained central/inferotemporal rod function.

    Conclusions:

    • The three identified patterns effectively categorize visual dysfunction in CRD.
    • Patterns showed consistency within families, suggesting genetic influence.
    • These classifications can aid in predicting disease course and understanding CRD heterogeneity.