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Related Experiment Videos

Biodegradable mechanical retinal fixation. A pilot study.

K R Olsen1, J M Parel, W Lee

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33101.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|May 1, 1989
PubMed
Summary
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Biodegradable biopins offer a safer alternative to metallic retinal tacks for vitreoretinal surgery. These temporary devices showed good intraocular tolerance in rabbits and degraded over time, reducing risks associated with permanent foreign bodies.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Veterinary Medicine

Background:

  • Metallic retinal tacks are used for mechanical retinal fixation in vitreoretinal surgery.
  • Permanent intraocular foreign bodies, like metallic tacks, carry risks of long-term toxic effects.
  • A temporary, biodegradable fixation device could mitigate these risks.

Purpose of the Study:

  • To evaluate the initial intraocular tolerance and degradation of a biodegradable mechanical retinal fixation device (biopin) in a rabbit model.
  • To compare the biopin with traditional metallic retinal tacks.
  • To explore the potential of biopins for sustained drug delivery in preventing vitreoretinal proliferation.

Main Methods:

  • A biodegradable biopin device was implanted in rabbit eyes.

Related Experiment Videos

  • Intraocular tolerance was assessed using light microscopy.
  • Disinsertion and degradation times of the biopins were recorded.
  • Outcomes were compared between eyes with biopins and those with metallic tacks, considering vitrectomy status.

    • Main Results:

    • Biopins demonstrated good intraocular tolerance with minimal light microscopic damage compared to metallic tacks.
    • Biopin disinsertion occurred within four weeks in all eyes.
    • Biopin degradation was observed at a median of six weeks in vitrectomized eyes and 12 weeks in non-vitrectomized eyes.
    • Differences in retinal detachment rates were noted between groups, suggesting varying mechanical stability.

    Conclusions:

    • The biodegradable biopin shows promise as a temporary retinal fixation device with good intraocular tolerance.
    • Biopins degrade over time, eliminating the long-term risks associated with permanent metallic tacks.
    • Biopins may serve as a platform for sustained pharmacologic agent delivery to prevent vitreoretinal proliferation and detachment.