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Molecularly imprinted nanohybrids based on dopamine-modified poly(γ-glutamic acid) for electrochemical sensing of
Rongli Zhang1, Sheng Xu2, Ye Zhu2
1Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China; School of Biochemical Engineering, Anhui Polytechnic University, Wuhu 241000, China.
Abstract:
A voltammetric sensor for melamine (MEL) was prepared from molecularly imprinted nanohybrids (MINBs). A dopamine modified poly-γ-glutamic acid copolymer (γ-PGA-DA) and MEL were self-assembled into MEL/γ-PGA-DA nanoparticles (NPs) in aqueous solution via weak interactions, followed by adding an aqueous AgNO3 solution into the mixture. The Ag(+) was adsorbed in the MEL/γ-PGA-DA NPs and spontaneously reduced to Ag NPs by the dopamine moieties of γ-PGA-DA, forming Ag/MEL/γ-PGA-DA MINBs, which were then cast on a gold electrode to form a MINBs film. The MEL was removed by electrolysis via catalysis of Ag NPs at a constant potential of 1.4V in phosphate buffer saline solution, to obtain a voltammetric sensor for MEL. The sensor responded linearly to MEL in the concentration range of 5×10(-18) to 5×10(-7)molL(-1). Compared to other published molecularly imprinted polymer sensors for sensing MEL, the prepared MINBs sensor had much wider detection range with lower detection limit.
