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Updated: Mar 21, 2026
Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
Published on: January 22, 2020
Signal enhancement in ligand-receptor interactions using dynamic polymers at quartz crystal microbalance sensors
Gunnar Dunér1, Henrik Anderson2, Zhichao Pei3
1KTH - Royal Institute of Technology, Department of Chemistry, Teknikringen 30, S-10044 Stockholm, Sweden. ramstrom@kth.se and Attana AB, Björnnäsvägen 21, S-11419 Stockholm, Sweden.
Abstract:
The signal enhancement properties of QCM sensors based on dynamic, biotinylated poly(acrylic acid) brushes has been studied in interaction studies with an anti-biotin Fab fragment. The poly(acrylic acid) sensors showed a dramatic increase in signal response with more than ten times higher signal than the carboxyl-terminated self-assembled monolayer surface.
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