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Identification of a novel HLA-C*03 variant, C*03:303, by sequence-based typing in a Dai Chinese individual

P C Su1, J Wang2, X Ji2

  • 1Transfusion Medicine Research Department, Yunnan Kunming Blood Center, Kunming, China.

HLA
|May 20, 2016
PubMed

Keywords:
HLA-C*03:303novel HLA allelesequence-based typing

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...