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Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
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Quality performance of laboratory testing in pharmacies: a collaborative evaluation.

Martina Zaninotto, Giorgia Miolo, Adriano Guiotto

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    Summary

    Pharmacy point-of-care testing (POCT) shows acceptable analytical performance, but pre- and post-analytical phases require improvement for accurate triglyceride and glucose measurements compared to laboratory results.

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    Area of Science:

    • Clinical Chemistry
    • Point-of-Care Testing
    • Laboratory Medicine

    Background:

    • Evaluating the quality and comparability of pharmacy point-of-care testing (POCT) against institutional laboratories is crucial for patient care.
    • Numerous analytical devices are utilized in community pharmacies for POCT.

    Purpose of the Study:

    • To assess the analytical performance and comparability of POCT devices used in pharmacies with results from institutional laboratories.
    • To identify potential discrepancies and areas for improvement in pharmacy-based testing.

    Main Methods:

    • Eight pharmacies participated, analyzing customer samples (n=106) using various POCT devices.
    • Simultaneously, physician-drawn samples were analyzed in a central laboratory for comparison.
    • Specific analytes including glucose, lipids, and liver enzymes were measured.

    Main Results:

    • Satisfactory correlation was observed for most parameters, except triglycerides, which showed higher median values in POCT.
    • Classification agreement varied, with notable differences in triglyceride and glucose levels between POCT and laboratory results.
    • Phase 2 analysis suggested pre-analytical issues contributed to triglyceride bias.

    Conclusions:

    • Pharmacy POCT demonstrates acceptable analytical performance for several key parameters.
    • Significant criticisms exist in the pre- and post-analytical phases of POCT, particularly impacting triglyceride measurements.
    • Improvements in pre- and post-analytical procedures are necessary to enhance the reliability of pharmacy-based POCT.