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Updated: Sep 3, 2026
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective Intra-Arterial Cold Saline Infusion
Jian Chen1, Liqiang Liu1, Hongqi Zhang1
1From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
Background And Purpose:
We conducted a pilot feasibility and safety study of selective brain cooling with intra-arterial infusion of cold saline combined with endovascular reperfusion for acute ischemic stroke.
Methods:
Patients with large-vessel occlusion within 8 hours after symptom onset were enrolled. All patients received intra-arterial recanalization combined with infusion of cold isotonic saline (4°C) in the ischemic territory through the angiographic catheter.
Results:
Twenty-six patients underwent the procedure, which was technically successful in all. The temperature of ischemic cerebral tissue was decreased by at least 2°C during infusion of the cold solution, and systemic temperature was mildly reduced (maximum 0.3°C). No obvious complications related to intra-arterial hypothermia were observed.
Conclusions:
Selective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.
