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[Dyslipidaemia and atherogenic risk in patients with systemic lupus erythematosus]

José Antonio de Jesús Batún Garrido1, Hugo Alberto Radillo Alba1, Éufrates Hernández Núñez2

  • 1Residente de tercer año de Medicina Interna, Hospital Regional de Alta Especialidad Dr. Gustavo A. Rovirosa Pérez, Villahermosa , Tabasco, México.

Medicina Clinica
|May 21, 2016
PubMed

Insights

Systemic lupus erythematosus patients often have dyslipidaemia, increasing cardiovascular risk. Higher disease activity and prednisone use are linked to dyslipidaemia, while hydroxychloroquine may be protective.

Area of Science:

  • Rheumatology
  • Cardiology
  • Metabolic Disorders

Background:

  • Dyslipidaemia is a frequent comorbidity in patients diagnosed with systemic lupus erythematosus (SLE).
  • This comorbidity contributes significantly to the overall health burden and cardiovascular risk in SLE patients.

Purpose of the Study:

  • To investigate the prevalence of dyslipidaemia in SLE patients.
  • To identify clinical and therapeutic factors associated with dyslipidaemia in this population.
  • To assess the atherogenic risk in SLE patients.

Main Methods:

  • A cohort of 51 patients with systemic lupus erythematosus was analyzed.
  • Data collected included disease variables, medication use, and calculated atherogenic risk indices.
  • Statistical analyses, including Chi square, ANOVA, and logistic regression, were employed to determine associations.

Main Results:

  • A high prevalence of dyslipidaemia was observed in 68.6% of the patients.
  • Significant associations were found between dyslipidaemia and disease activity (SLEDAI), lupus nephritis, and prednisone use (≥20mg/day).
  • Conversely, hydroxychloroquine use showed a significant association with the absence of dyslipidaemia.

Conclusions:

  • Patients with SLE exhibit a high prevalence of dyslipidaemia and elevated atherogenic risk.
  • Factors such as high disease activity (SLEDAI≥4) and significant prednisone use are independently associated with increased dyslipidaemia.
  • These findings underscore the heightened cardiovascular risk in SLE patients and highlight potential therapeutic targets.
Abstract

Keywords:
Atherogenic indexDislipidemiaDyslipidaemiaLupus eritematoso sistémicoSystemic lupus erythematosusÍndice aterogénico

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