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    Hepatitis C Virus (HCV) patients with compensated cirrhosis who achieve sustained virologic response (SVR) can expect a normal life expectancy. Early treatment is crucial to prevent cirrhosis and reduce hepatocellular carcinoma risk.

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    Area of Science:

    • Hepatology
    • Virology
    • Public Health

    Background:

    • Sustained virologic response (SVR) improves outcomes in chronic Hepatitis C Virus (HCV) infection.
    • Previous studies demonstrated improved outcomes but not normal life expectancy for HCV patients achieving SVR.

    Purpose of the Study:

    • To determine if patients with compensated cirrhosis who achieve SVR have a life expectancy similar to the general population.
    • To assess long-term survival and hepatocellular carcinoma (HCC) incidence in treated HCV cirrhotic patients.

    Main Methods:

    • Historical prospective cohort studies.
    • Inclusion of patients from tertiary referral centers in Italy.
    • Comparison of patient survival data with Italian national data for 10- and 20-year survival.

    Main Results:

    • Patients with compensated cirrhosis achieving SVR demonstrated a life expectancy comparable to the general population.
    • A trend towards worse survival was noted in patients with Child-Pugh class A6 compared to A5.
    • Hepatocellular carcinoma (HCC) incidence post-SVR was significant, highlighting the importance of early intervention.

    Conclusions:

    • Achieving SVR can normalize life expectancy for Hepatitis C Virus cirrhotic patients.
    • Early HCV treatment is essential to prevent cirrhosis development, the primary determinant of HCC.
    • Continued monitoring for HCC is necessary even after achieving SVR in cirrhotic patients.