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Use of antipsychotics and risk of myocardial infarction: a systematic review and meta-analysis

Zheng-He Yu1, Hai-Yin Jiang2, Li Shao2

  • 1Department of Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou, 310013, PR China.

British Journal of Clinical Pharmacology
|May 21, 2016
PubMed
Abstract

Insights

Antipsychotic medications are linked to a higher risk of myocardial infarction (MI). This review found antipsychotic users had 1.88 times greater odds of developing MI, with a more pronounced risk in short-term users.

Area of Science:

  • Cardiology
  • Psychopharmacology
  • Epidemiology

Background:

  • Emerging concerns link antipsychotic use to increased myocardial infarction (MI) risk.
  • Previous reviews had limitations in accurately estimating this association.
  • Recent studies show conflicting results regarding antipsychotic drug use and MI.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis of observational studies.
  • To determine if antipsychotic use impacts the risk of myocardial infarction (MI).

Main Methods:

  • Systematic review and meta-analysis of observational studies.
  • Included studies compared MI incidence in antipsychotic users versus non-users.
  • Analyzed nine observational studies.

Main Results:

  • Antipsychotic users had 1.88-fold higher odds of developing MI (OR 1.88, 95% CI 1.39-2.54).
  • Subgroup analysis revealed higher odds for schizophrenia patients (OR 2.48, 95% CI 1.66-3.69).
  • Short-term (<30 days) antipsychotic users showed significantly increased odds (OR 2.64, 95% CI 2.48-2.81).

Conclusions:

  • Findings support an increased risk of MI associated with antipsychotic drug use.
  • This meta-analysis highlights a more pronounced risk in short-term antipsychotic users.
  • The study expands on previous knowledge regarding antipsychotics and cardiovascular risk.
Keywords:
antipsychotic agentscoronary diseasemyocardial infarction

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