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Clogging-free microfluidics for continuous size-based separation of microparticles.

Yousang Yoon¹, Seonil Kim¹, Jusin Lee¹

¹Department of Electronic Engineering, Hanyang Universtiy, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.

Scientific Reports

|May 21, 2016

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This study introduces microfluidic sieving (μ-sieving) with fluid oscillation to prevent filter clogging. This technique enables continuous particle and cancer cell separation with high efficiency and retrieval rates.

Area of Science:

Microfluidics
Biotechnology
Particle Separation

Background:

Microfluidic filtration systems often face clogging, hindering continuous operation.
Efficient and continuous microfluidic separation remains a significant challenge.

Purpose of the Study:

To introduce a novel microfluidic sieving (μ-sieving) technique.
To overcome filter clogging and enable continuous microfluidic separation.

Main Methods:

Incorporation of low-frequency mechanical oscillation into fluid flow.
Utilizing μ-sieving for separating polystyrene particles and cancer cells from whole blood.

Main Results:

Achieved 100% separation efficiency for target polystyrene particles.

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Demonstrated continuous μ-sieving operation with high particle retrieval rates (>98%).

Successfully applied μ-sieving to continuous cancer cell separation from whole blood, preventing filter blockage.

Conclusions:

The μ-sieving technique effectively prevents filter clogging through fluid oscillation.
This method allows for continuous, high-efficiency microfluidic separation with minimal system stress.
The technique shows promise for both particle separation and biomedical applications like cancer cell isolation.