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Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture)

¹Howard Hughes Medical Institute and Department of Biochemistry, Duke University, Medical Center, Durham, NC, 27710, USA. modrich@biochem.duke.edu.

Angewandte Chemie (International Ed. in English)

|May 21, 2016

Abstract:

DNA molecules are not completely stable, they are subject to chemical or photochemical damage and errors that occur during DNA replication resulting in mismatched base pairs. Through mechanistic studies Paul Modrich showed how replication errors are corrected by strand-directed mismatch repair in Escherichia coli and human cells.

Keywords:

DNA repair Nobel lecture endonucleases mismatch

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