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[Substantia innominata kindling in rats]
S Hoshino1, N Mori, H Kumashiro
1Department of Neuropsychiatry, Fukushima Medical College, Japan.
No to Shinkei = Brain and Nerve
|January 1, 1989
Summary
Cholinergic neurons in the substantia innominata (SI) influence amygdala (AM) kindling. Electrical stimulation of the SI can trigger generalized seizures, suggesting its role in seizure generalization.
Area of Science:
- Neuroscience
- Epileptology
- Neuroanatomy
Background:
- Cholinergic neurons in the substantia innominata (SI) are implicated in amygdala (AM) kindling.
- Previous studies suggest SI's role in motor system access during AM kindling.
Purpose of the Study:
- To investigate the role of the substantia innominata (SI) in amygdala (AM) kindling.
- To compare electroclinical features of AM and SI kindling.
- To assess the transferability of kindling from SI to the ipsilateral AM.
Main Methods:
- Electrical kindling of the left amygdala (AM) or substantia innominata (SI) in male Wistar rats.
- Determination of afterdischarge threshold (ADT) and generalized seizure triggering threshold (GST).
- Histological verification of electrode placements.
Main Results:
- Kindling was achieved in rats with electrodes in the medial SI, lateral SI, Globus Pallidus (GP), and Nucleus Accumbens (NA).
- All rats with electrodes in the AM were successfully kindled.
- Successful kindling was observed in 3/5 GP rats and 2/2 NA rats.
Conclusions:
- The substantia innominata (SI) plays a role in amygdala (AM) kindling and seizure generalization.
- Electrical stimulation of the SI can induce generalized seizures, supporting its involvement in the kindling process.
- Further research is needed to elucidate the precise mechanisms of SI involvement in AM kindling.