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Long lasting respiratory depression induced by morphine-6-glucuronide?
J Hasselström1, U Berg, A Löfgren
1Department of Clinical Pharmacology, Huddinge Hospital, Karolinska Institute, Sweden.
British Journal of Clinical Pharmacology
|April 1, 1989
Summary
A child with haemolytic uraemic syndrome experienced prolonged respiratory depression after morphine. Elevated levels of morphine
Area of Science:
- Pharmacology
- Nephrology
- Pediatrics
Background:
- Morphine is an opioid analgesic used for pain management.
- Haemolytic uraemic syndrome (HUS) is a serious condition affecting the kidneys and blood.
- Drug metabolism can be altered in patients with renal impairment.
Observation:
- A 7-year-old girl with HUS received intravenous morphine.
- The patient exhibited prolonged respiratory depression post-administration.
Findings:
- Plasma concentrations of morphine's active metabolite, M6G, were over 10 times higher than usual.
- The elimination half-lives of both M6G and morphine were significantly prolonged in this patient.
Implications:
- This case highlights potential risks of morphine use in pediatric HUS patients.
- Altered drug metabolism in HUS may necessitate dose adjustments and careful monitoring.
- Further research is needed to establish safe morphine dosing guidelines for HUS patients.