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Ethosomes and Transfersomes: Principles, Perspectives and Practices.

Varun Garg1, Harmanpreet Singh1, Sneha Bimbrawh1

  • 1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara -144411, Punjab, India.

Current Drug Delivery
|May 21, 2016
PubMed
Summary

Elastic vesicles like ethosomes and transfersomes enhance transdermal drug delivery by improving skin penetration and bioavailability. This review details their principles, preparation, and applications for effective drug delivery systems.

Keywords:
Elastic vesiclesethosomesliposomesnanomedicinephospholipidtransdermal drug deliverytransfersomes

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Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Liposomes have shown success in treating diseases, inspiring the development of elastic vesicles for transdermal delivery.
  • Ethosomes and transfersomes were engineered to facilitate drug passage through the skin.
  • A systematic review is needed to outline principles, preparation, advancements, and applications of these elastic vesicles.

Purpose of the Study:

  • To provide a comprehensive overview of ethosomes and transfersomes.
  • To elucidate the principles, preparation methods, and mechanisms of action of these vesicular systems.
  • To highlight the advantages and applications of ethosomes and transfersomes in transdermal drug delivery.

Main Methods:

  • A structured search of bibliographic databases for peer-reviewed research and review articles was conducted.
  • Data was compiled on the principles, composition, mechanisms, preparation techniques, characterization, and applications of ethosomes and transfersomes.
  • A total of 182 relevant papers were included for a comprehensive review.

Main Results:

  • Ethosomes utilize ethanol for enhanced skin penetration, while transfersomes rely on elasticity and edge activators.
  • Both systems offer advantages in drug permeation, sustained release, and protection of encapsulated actives.
  • Various preparation methods, including rotary film evaporation and ethanol injection, were discussed with their benefits.
  • Successful delivery of both synthetic drugs and phytomedicines via these elastic nanocarriers has been reported.

Conclusions:

  • Ethosomes and transfersomes show significant potential for rational transdermal drug delivery.
  • Optimizing process variables through thoughtful design is crucial for maximizing their efficacy.
  • Industrial-scale production of stable, cost-effective, and safe formulations is essential for their widespread use as transdermal vehicles.