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HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

Till Schoofs1, Florian Klein2, Malte Braunschweig3

  • 1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Science (New York, N.Y.)
|May 21, 2016
PubMed

3BNC117 is a broad and potent neutralizing antibody to HIV-1 that targets the CD4 binding site on the viral envelope spike. When administered passively, this antibody can prevent infection in animal models and suppress viremia in HIV-1-infected individuals. Here we report that HIV-1 immunotherapy with a single injection of 3BNC117 affects host antibody responses in viremic individuals. In comparison to untreated controls that showed little change in their neutralizing activity over a 6-month period, 3BNC117 infusion significantly improved neutralizing responses to heterologous tier 2 viruses in nearly all study participants. We conclude that 3BNC117-mediated immunotherapy enhances host humoral immunity to HIV-1.

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