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Correlation between Serum Osteopontin and miR-181a Levels in Allergic Rhinitis Children
Wenlong Liu1, Qingxiang Zeng1, Renzhong Luo1
1Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, No. 9 Jinsui Road, Guangzhou 510623, China.
Background:
Osteopontin (OPN) has been proved to be associated with allergic airway inflammation. However, the roles of OPN and its regulation in childhood allergic rhinitis (AR) are poorly understood.
Objective:
This study aims to evaluate the expression of OPN and miR-181a in children with AR and their association with Th1/Th2 immune response.
Methods:
Children who suffered from AR were included along with control subjects. Serum was collected to examine the level of OPN and Th1/Th2 cytokines by enzyme-linked immunosorbent assay (ELISA) and the level of miR-181a by quantitative polymerase chain reaction (qPCR).
Results:
Children with AR had significantly higher serum levels of OPN and lower serum levels of miR-181a than healthy controls. Furthermore, serum levels of OPN were positively correlated with Th2 cytokine and negatively correlated with Th1 cytokine. On the contrary, miR-181a level had a negative correlation with IL-4/IL-5 and positive correlation with IFN-γ/IL-12. More importantly, there was also significant negative correlation between OPN and miR-181a.
Conclusion:
The OPN protein and miR-181a levels may serve as predictors of disease severity in childhood AR and appear to be promising targets for modulating AR.
