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Free tryptophan decrease in jaundiced newborn infants during phototherapy.

E Zammarchi1, S La Rosa, U Pierro

  • 1Department of Pediatrics, University of Florence, Italy.

Biology of the Neonate
|January 1, 1989
PubMed
Summary
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Phototherapy for infant jaundice significantly lowers nonesterified fatty acids (NEFA) and free tryptophan. These changes may impact the brain

Area of Science:

  • Biochemistry
  • Neonatal Medicine
  • Neuroscience

Background:

  • Serum albumin binds both nonesterified fatty acids (NEFA) and tryptophan.
  • NEFA can displace tryptophan from albumin binding sites.
  • Phototherapy is a common treatment for neonatal jaundice.

Purpose of the Study:

  • To investigate the relationship between NEFA and tryptophan levels in jaundiced newborns undergoing phototherapy.
  • To examine the impact of phototherapy on free tryptophan concentrations.

Main Methods:

  • Blood samples were collected from jaundiced newborn infants before and after phototherapy.
  • Levels of nonesterified fatty acids (NEFA), total tryptophan, and free tryptophan were measured.
  • Statistical analysis was performed to assess significant changes.

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Main Results:

  • A significant decrease in NEFA levels was observed after 24 hours of phototherapy (p < 0.001).
  • A significant decrease in free tryptophan levels was also observed (p < 0.001).
  • Total tryptophan levels were not explicitly mentioned as significantly changed, focus is on free form.

Conclusions:

  • Phototherapy leads to a concurrent reduction in NEFA and free tryptophan in jaundiced newborns.
  • The observed decrease in free tryptophan may influence the transport of tryptophan across the blood-brain barrier.
  • This alteration in free tryptophan could potentially affect the synthesis of the cerebral neurotransmitter serotonin (5-hydroxytryptamine).