Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A disequilibrium coefficient approach to Hardy-Weinberg testing.

J L Hernández1, B S Weir

  • 1Department of Statistics, North Carolina State University, Raleigh 27695-8203.

Biometrics
|March 1, 1989
PubMed
Summary

This study compares Hardy-Weinberg equilibrium tests, highlighting probability tests for small samples and disequilibrium coefficients for multiple alleles. These methods offer robust analysis of genetic population data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A three-level model of diffuse idiopathic skeletal hyperostosis (DISH): Integrating susceptibility, activation, and clinical trajectories.

Bone·2026
Same author

Metabolic and osteogenic susceptibility in DISH: A prognostic index from propensity score modelling.

Bone·2026
Same author

Global diversity analysis of plant-associated <i>Pseudopithomyces</i> fungi reveals a new species producing the toxin associated with facial eczema in livestock: <i>Pseudopithomyces toxicarius sp. nov</i>.

Studies in mycology·2026
Same author

<i>Fusarium</i>: more than a node or a foot-shaped basal cell.

Studies in mycology·2021
Same author

Understanding the local and remote source contributions to ambient O<sub>3</sub> during a pollution episode using a combination of experimental approaches in the Guadalquivir valley, southern Spain.

The Science of the total environment·2021
Same author

Vertebral fractures are increased in rheumatoid arthritis despite recent therapeutic advances: a case-control study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021

Area of Science:

  • Population Genetics
  • Statistical Genetics

Background:

  • Hardy-Weinberg equilibrium is a fundamental principle in population genetics.
  • Assessing deviations from this equilibrium is crucial for understanding evolutionary processes.
  • Existing tests have limitations, especially with multiple alleles and small sample sizes.

Purpose of the Study:

  • To compare various statistical tests for Hardy-Weinberg equilibrium.
  • To evaluate methods suitable for multiple alleles and small sample sizes.
  • To introduce and validate the use of disequilibrium coefficients.

Main Methods:

  • Comparison of classical chi-square goodness-of-fit tests with and without continuity corrections.
  • Application of probability tests for small sample sizes and multiple alleles.

Related Experiment Videos

  • Utilizing disequilibrium coefficients and likelihood-ratio tests for analyzing departures from equilibrium.

    • Main Results:

    • Continuity-corrected chi-square tests are conservative; uncorrected tests are less so.
    • Probability tests are preferable for small samples, especially with multiple alleles.
    • Disequilibrium coefficients provide insights into the nature of deviations and can be tested using chi-square approximations.

    Conclusions:

    • The chi-square goodness-of-fit test is generally effective, with continuity corrections advised for extreme cases.
    • Probability tests offer a robust alternative for small sample sizes and multiple alleles.
    • Disequilibrium coefficients provide a practical and effective method for analyzing multi-allelic genetic data without complex calculations.