Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spinal osteoporosis in men.

R M Francis1, M Peacock, D H Marshall

  • 1Newcastle General Hospital, England.

Bone and Mineral
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The future of citizen science for marine litter research: What are the benefits to be realised and the challenges to be overcome?

Marine pollution bulletin·2025
Same author

Tradeoffs and synergies in wetland multifunctionality: A scaling issue.

The Science of the total environment·2022
Same author

Small artificial waterbodies are widespread and persistent emitters of methane and carbon dioxide.

Global change biology·2021
Same author

Overriding water table control on managed peatland greenhouse gas emissions.

Nature·2021
Same author

Designing a mHealth clinical decision support system for Parkinson's disease: a theoretically grounded user needs approach.

BMC medical informatics and decision making·2020
Same author

Whole egg consumption and cortical bone in healthy children.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same journal

Response to letter 'Stereological considerations concerning the measurement of individual osteoid seams and resorption cavities'.

Bone and mineral·1994
Same journal

Gender-related effects of vitamin D metabolites on cartilage and bone.

Bone and mineral·1994
Same journal

Ascites sarcoma 180, a tumor associated with hypercalcemia, secretes potent bone-resorbing factors including transforming growth factor alpha, interleukin-1 alpha and interleukin-6.

Bone and mineral·1994
Same journal

Effect of nandrolone decanoate and 1-alpha-hydroxy-calciferol on patients with vertebral osteoporotic collapse. A double-blind clinical trial.

Bone and mineral·1994
Same journal

Basic fibroblast growth factor (BFGF) immunoreactivity as a possible link between head injury and impaired bone fracture healing.

Bone and mineral·1994
Same journal

Assessment of bone density in the distal radius with computer assisted X-ray densitometry (CXD).

Bone and mineral·1994
See all related articles

Primary osteoporosis in men is characterized by reduced bone density and impaired calcium absorption. This study found lower bone volume and trabecular number in men with osteoporosis compared to healthy individuals.

Area of Science:

  • Bone biology and osteoporosis research.

Background:

  • Primary osteoporosis affects a significant number of men presenting with crush fractures.
  • Age-related changes in bone health are well-documented in healthy men.

Purpose of the Study:

  • To compare bone-related variables in men with primary osteoporosis to healthy age-matched controls.
  • To identify key differences in bone structure, mineral metabolism, and hormonal profiles.

Main Methods:

  • Cross-sectional study comparing 40 men with primary osteoporosis to healthy men aged 20-96.
  • Measurements included bone dimensions (cortical area, bone volume, trabecular number), calcium absorption, and plasma hormone levels.
  • Iliac crest biopsy and radiocalcium absorption tests were performed.

Main Results:

Related Experiment Videos

  • Men with primary osteoporosis exhibited reduced femoral cortical area/total area and Singh grade.
  • Bone volume and trabecular number were significantly decreased on iliac crest biopsy.
  • Impaired radiocalcium absorption and reduced plasma 1,25-dihydroxyvitamin D levels were observed, leading to negative calcium balance.

Conclusions:

  • Primary osteoporosis in men is associated with diminished bone mass and structural integrity.
  • Reduced calcium absorption, potentially linked to lower vitamin D levels, contributes to negative calcium balance.
  • These findings highlight distinct pathophysiological mechanisms in male osteoporosis.