Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glial Cells

Glial Cells

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism.

Nature·2026

Same author

Pain across time.

Science (New York, N.Y.)·2026

Same author

Microglial reactivity and neuroinflammation-driven changes in motivational behaviors are regulated by Orai1 calcium channels.

Science signaling·2026

Same author

Recommendations for the inclusion and study of sex and gender in research.

Nature neuroscience·2025

Same author

Protein-protein interaction-interfering peptide rescues dysregulated NMDA receptor signaling.

JCI insight·2025

Same author

Antisense oligonucleotides reverse SPTLC1-related hereditary sensory neuropathy in a mouse model.

Brain : a journal of neurology·2025

Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026

Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026

Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026

Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026

Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026

Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 20, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

SnapShot: Microglia in Disease.

Simon Beggs¹, Michael W Salter²

¹Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto ON M5G 1X8, Canada; Developmental Neurosciences Programme, UCL Institute of Child Health, London WC1N 1EH, UK.

|May 21, 2016

Summary

This summary is machine-generated.

Microglia are crucial for healthy brain development and function. Their dysfunction is linked to serious neurological conditions, including autism, Alzheimer

More Related Videos

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

Related Experiment Videos

Last Updated: Mar 20, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

Area of Science:

Neuroscience
Immunology
Cell Biology

Background:

Microglia, the resident immune cells of the central nervous system (CNS), play a vital role in brain development and maintenance.
Their homeostatic functions include sculpting and refining neuronal circuitry, essential for proper nervous system function.
Dysregulation of microglial activity is implicated in the pathology of various neurological disorders.

Purpose of the Study:

To elucidate the critical role of microglia in central nervous system (CNS) development and homeostasis.
To investigate the contribution of microglial dysregulation to the pathogenesis of neurodevelopmental and neurodegenerative disorders.
To highlight the involvement of microglia in conditions such as autism spectrum disorders, Alzheimer's disease, schizophrenia, and chronic neuropathic pain.

Main Methods:

This study synthesizes current research on microglial function and dysfunction.
Utilizes a review-based approach, analyzing existing literature on microglial roles in CNS health and disease.
Focuses on the molecular and cellular mechanisms underlying microglial involvement in neurological pathologies.

Main Results:

Regulated microglial actions are essential for the development and maintenance of the CNS.
Microglia actively sculpt and refine neuronal connections throughout development.
Aberrant microglial activity is a common feature across a spectrum of neurological disorders.

Conclusions:

Microglia are indispensable for maintaining central nervous system (CNS) health through regulated homeostatic functions.
Disruptions in microglial function are directly linked to the development and progression of significant neurological and psychiatric conditions.
Targeting microglial pathways presents a potential therapeutic avenue for treating disorders like autism, Alzheimer's, and schizophrenia.