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[Potentially toxic antibiotics concentrations after administration using impregnated dressing in a severe burned

Julien Dupouey1, Sandrine Wiramus2, Jacques Albanese2

  • 1Service de pharmacologie clinique et pharmacovigilance, laboratoire de pharmacologie clinique, hôpital de la Timone, CHU de la Timone, AP-HM, 13385 Marseille, France.

Therapie
|May 21, 2016
PubMed

Insights

For severe burn infections, amikacin and colistin dressings offer localized antibiotic delivery. This case study examines systemic exposure and pharmacokinetics, crucial for preventing toxicity in burn patients.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Burn Care

Background:

  • Severe burn patients face high risks of skin infections, often caused by Pseudomonas aeruginosa.
  • Topical antibiotic delivery via impregnated dressings (amikacin, colistin) is explored for localized treatment.
  • Current antibiotic monitoring focuses on intravenous administration, with limited data on dressing-based delivery.

Observation:

  • A case report details a severe burn patient with a cutaneous infection.
  • The patient received treatment using amikacin and colistin impregnated dressings.
  • Plasmatic pharmacokinetic profiles were assessed during treatment.

Findings:

  • Impregnated dressings provide direct antibiotic concentration at the infection site.
  • Systemic exposure and potential toxicity risks require further investigation.
  • Pharmacokinetic data from this case inform future therapeutic strategies.

Implications:

  • This study highlights the need for therapeutic drug monitoring for topical antibiotic dressings.
  • Understanding systemic absorption is vital for optimizing burn wound infection treatment.
  • Further research can establish safety and efficacy profiles for antibiotic-impregnated dressings.
Keywords:
AminoglycosidAminoglycosidesBrûlureBurnsColimycineColistinCutaneus infectionInfection cutanéeSuivi thérapeutique pharmacologiqueTherapeutic drug monitoring

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