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Elective single embryo transfer: Is frozen better than fresh?
Hala Gomaa1, Rania Baydoun1, Sakina Sachak1
1NewLife Fertility Center, Mississauga, Ontario, Canada.
JBRA Assisted Reproduction
|May 21, 2016
Summary
Frozen embryo transfer resulted in higher pregnancy and live birth rates compared to fresh embryo transfer in single embryo transfer (SET) procedures for women aged 39 and under. This finding supports optimizing assisted reproductive technology outcomes.
Area of Science:
- Reproductive Medicine
- Assisted Reproductive Technology (ART)
Background:
- Single embryo transfer (SET) is recommended to reduce multiple births in ART.
- Frozen embryo transfer (FET) may offer superior pregnancy rates compared to fresh embryo transfer (FT).
Purpose of the Study:
- To compare pregnancy and live birth rates between fresh and frozen single embryo transfer in age-matched infertile women.
Main Methods:
- Retrospective case control study at a private fertility clinic.
- Compared outcomes of elective single embryo transfer (eSET) with fresh versus frozen embryos.
- Primary endpoints: positive hCG, ongoing pregnancy; Secondary endpoints: live birth, miscarriage.
Main Results:
- 583 eSET cycles analyzed (212 fresh, 371 frozen).
- Significantly higher pregnancy and live birth rates observed in patients aged ≤ 39 years receiving frozen embryos.
Conclusions:
- Frozen single embryo transfer is associated with improved pregnancy and live birth rates over fresh transfer.
- FET may be a preferred strategy for optimizing ART success in specific patient demographics.
