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Related Experiment Videos

Performance studies with antihistamines.

C H Clarke, A N Nicholson

    British Journal of Clinical Pharmacology
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Four antihistamines were tested for effects on cognitive function. Chlorpheniramine, clemastine, and promethazine impaired visuo-motor coordination, while terfenadine showed no significant performance effects.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Human Physiology

    Background:

    • Antihistamines are commonly used for allergy relief.
    • Some antihistamines are known to cross the blood-brain barrier and cause central nervous system effects.
    • Understanding the cognitive impact of different antihistamines is crucial for patient safety and informed prescribing.

    Purpose of the Study:

    • To compare the effects of four antihistamines (chlorpheniramine, clemastine, promethazine, terfenadine) on visuo-motor coordination and subjective well-being.
    • To assess the duration of these effects after a single oral dose.
    • To evaluate potential differences in central nervous system side effects among these antihistamines.

    Main Methods:

    • A double-blind, placebo-controlled study involving six healthy female participants.

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  • Administration of single oral doses of chlorpheniramine (4 mg), clemastine (1 mg), promethazine (10 mg), and terfenadine (60 mg), compared to placebo.
  • Assessment of visuo-motor coordination and subjective well-being at various time points (0.5–7.0 hours) post-ingestion.

    • Main Results:

    • Impaired visuo-motor coordination was observed after chlorpheniramine (1.5h), clemastine (3.0h, 5.0h), and promethazine (3.0h, 5.0h).
    • No significant effects on performance were detected with terfenadine.
    • Subjective assessments of performance remained unaltered across all drug conditions.
    • Terfenadine ingestion led to reported improvements in alertness and wakefulness; chlorpheniramine was associated with reduced energy levels at 7.0h.

    Conclusions:

    • Certain first-generation antihistamines like chlorpheniramine, clemastine, and promethazine can significantly impair visuo-motor coordination.
    • Terfenadine, a second-generation antihistamine, did not demonstrate significant adverse effects on cognitive performance in this study.
    • These findings highlight the importance of considering the potential for central nervous system side effects when selecting antihistamines, particularly for tasks requiring alertness and coordination.