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Fast and sensitive multiple sequence alignments on a microcomputer.

D G Higgins1, P M Sharp

  • 1Department of Genetics, Trinity College, Dublin, Ireland.

Computer Applications in the Biosciences : CABIOS
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

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This study introduces a fast method for aligning numerous long DNA or protein sequences using microcomputers. The new phylogenetic tree-based approach is as sensitive as existing alignment techniques.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Multiple sequence alignment is crucial for understanding biological relationships.
  • Existing methods can be computationally intensive for large datasets.

Purpose of the Study:

  • To develop a rapid and efficient strategy for aligning numerous long nucleic acid or protein sequences.
  • To implement this strategy on a microcomputer.

Main Methods:

  • A progressive alignment approach guided by an initial phylogenetic tree.
  • The program accommodates up to 100 sequences, each up to 1200 residues long.

Main Results:

  • The developed program enables rapid alignment of large sequence datasets.

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  • The alignment sensitivity is comparable to other established methods.

    • Conclusions:

    • This strategy offers a viable solution for large-scale sequence alignment on microcomputers.
    • The method provides sensitive results efficiently.