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Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: A

Dominique M IJff1, Debby Postulart2, Danielle A J E Lambrechts3

  • 1Department of Behavioral Sciences, Epilepsy Center Kempenhaeghe, Heeze, The Netherlands; MHENS School of Mental Health & Neuroscience, Maastricht University, Maastricht, The Netherlands.

Epilepsy & Behavior : E&B
|May 21, 2016
PubMed

Insights

The ketogenic diet (KD) positively impacts behavior and cognition in children with refractory epilepsy. This study found improved mood, reduced anxiety, and enhanced cognitive function in children on the KD.

Area of Science:

  • Pediatric Neurology
  • Neuroscience
  • Clinical Nutrition

Background:

  • Refractory epilepsy in childhood is a significant clinical challenge.
  • The ketogenic diet (KD) is recognized for its efficacy in seizure reduction.
  • Objective assessment of KD's cognitive and behavioral effects is crucial.

Purpose of the Study:

  • To evaluate the impact of the ketogenic diet (KD) on cognitive and behavioral outcomes in children and adolescents with refractory epilepsy.
  • To compare these outcomes between a KD group and a care-as-usual (CAU) control group.
  • To assess changes within the first four months of KD initiation.

Main Methods:

  • A randomized controlled trial was conducted with pediatric epilepsy patients.
  • Participants were assigned to either the KD intervention group or the CAU control group.
  • Cognition and behavior were assessed at four months using parent questionnaires and psychological tests.

Main Results:

  • The KD group (n=28) demonstrated lower levels of anxious and mood-disturbed behaviors compared to the CAU group (n=22).
  • Children in the KD group were rated as more productive.
  • Cognitive testing revealed improved activation in the KD group.

Conclusions:

  • The ketogenic diet (KD) shows a positive effect on behavioral and cognitive functioning in pediatric refractory epilepsy.
  • Specifically, KD treatment was associated with enhanced mood and cognitive activation.
  • These findings support the use of KD for improving overall functioning in this population.
Abstract

Keywords:
BehaviorCognitionEpilepsyKetogenic diet

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