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Association between cystatin C and heart failure with preserved ejection fraction in elderly Chinese patients

C C Xu1, G X Fu1, Q Q Liu2

  • 1Department of Geriatrics, Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital, 600 Yishan Road, 200233, Xuhui District, Shanghai, China.

Zeitschrift Fur Gerontologie Und Geriatrie
|May 22, 2016
PubMed

Insights

Higher cystatin C levels in elderly Chinese patients with heart failure with preserved ejection fraction (HFpEF) are linked to worse heart function and diastolic properties, independent of kidney function.

Area of Science:

  • Cardiology
  • Biomarkers
  • Geriatrics

Background:

  • Heart failure with preserved ejection fraction (HFpEF) affects approximately 50% of heart failure patients.
  • Cystatin C is a known marker associated with cardiovascular events.
  • Investigating cystatin C's role in HFpEF cardiac function is crucial.

Purpose of the Study:

  • To determine the association between serum cystatin C levels and cardiac function in elderly Chinese HFpEF patients.
  • To assess the relationship between cystatin C and cardiac diastolic properties, including the early (E) to late (A) transmitral flow velocity ratio (E/A ratio).

Main Methods:

  • A cross-sectional study included 381 elderly Chinese HFpEF patients.
  • Serum cystatin C, N-terminal pro brain natriuretic peptide (NT-proBNP), and New York Heart Association (NYHA) classification were assessed.
  • E/A ratios were measured to evaluate cardiac diastolic properties.

Main Results:

  • Cystatin C levels significantly correlated with NYHA class (r=0.605, P<0.001) and were negatively correlated with E/A ratio (r=-0.224, P=0.005).
  • Higher cystatin C levels were associated with a lower E/A ratio, indicating impaired diastolic function.
  • These associations remained significant even after adjusting for creatinine clearance rate (CCr).

Conclusions:

  • Serum cystatin C is associated with NYHA classification and abnormal cardiac diastolic properties in elderly Chinese HFpEF patients.
  • Cystatin C serves as a valuable biomarker for assessing cardiac function in HFpEF, independent of renal function.
  • Further research may elucidate cystatin C's role in HFpEF pathogenesis and management.
Abstract

Keywords:
Cystatin CDiastolic propertiesElderlyHeart failure with preserved ejection fractionNYHA classification

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