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Related Experiment Video

Updated: Mar 20, 2026

Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization
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Ex vivo laser lipolysis assisted with radially diffusing optical applicator.

Jieun Hwang1, Nguyen Trung Hau2, Sung Yeon Park3

  • 1Pukyong National University, Department of Biomedical Engineering, Busan 48513, Republic of Korea.

Journal of Biomedical Optics
|May 22, 2016
PubMed
Summary
This summary is machine-generated.

A novel radially diffusing optical applicator offers a safer and more effective method for laser lipolysis. This new device reduces thermal injury and liquefies more adipose tissue compared to traditional flat fibers.

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Area of Science:

  • Biomedical Engineering
  • Optical Engineering
  • Dermatology

Background:

  • Laser-assisted lipolysis utilizes thermal effects on adipose tissue for body fat reduction.
  • Current methods using flat fibers can lead to undesirable thermal injury and require rapid movements due to direct tissue contact.

Purpose of the Study:

  • To evaluate the feasibility of a radially diffusing optical applicator for laser lipolysis.
  • To compare the efficacy of the diffuser versus a flat fiber in terms of temperature elevation and adipose tissue liquefaction.

Main Methods:

  • A 980-nm wavelength laser was used to compare a radially diffusing applicator with a flat fiber.
  • Temperature changes and adipose tissue liquefaction were measured in ex vivo tissue tests.
  • Irradiation was performed at a consistent power of 20 W for up to 5 minutes.

Main Results:

  • The diffusing applicator resulted in a 30% slower temperature increase and a 25% lower maximum temperature (84±3.2°C) compared to the flat fiber.
  • Under equivalent thermal conditions, the diffuser liquefied a fivefold larger area of adipose tissue.
  • Ex vivo tests showed the diffuser liquefied 66% more adipose tissue (1.24±0.15g) than the flat fiber (0.75±0.05g) within 5 minutes.

Conclusions:

  • The radially diffusing optical applicator is a feasible therapeutic device for laser lipolysis.
  • The diffuser offers advantages of lower temperature development and wider thermal treatment coverage.
  • This technology presents a potentially safer and more effective alternative to current laser lipolysis methods.