Related Experiment Video
Updated: Aug 19, 2026

Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
[Experimental models of gastric ulcers. Changes in the secretion of gastric glycoproteins in selected types]
Abstract:
The authors discuss possibilities of modelling of gastric ulcers in experiments on small laboratory animals. In four types of acute gastric ulcers and one type of chronic ulcer changes of glycoproteins in gastric mucus were investigated as to glycoproteins a protective effect on the gastric mucosa is ascribed. As indicator of secretion of these substances total hexose and total protein values were used. It was revealed that in homogenates the total hexose values were in all types of ulcers higher than in the control group. Total protein values were elevated in three types of ulcers. Elevated values of these substances were found also in gastric juice in ulcers after ligature of the pylorus.
More Related Videos
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Gastritis II: Pathophysiology

