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A Protocol for Analyzing Hepatitis C Virus Replication
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A Protocol for Analyzing Hepatitis C Virus Replication

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Hepatitis C and risk of coronary atherosclerosis - A systematic review

O O Olubamwo1, A O Aregbesola1, J Miettola1

  • 1Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Public Health
|May 22, 2016
PubMed

Insights

Chronic hepatitis C infection triples the risk of developing coronary atherosclerosis and increases its severity. However, evidence linking hepatitis C to related cardiovascular events remains inconclusive.

Area of Science:

  • Cardiology
  • Hepatology
  • Epidemiology

Background:

  • Observational studies on chronic hepatitis C and coronary atherosclerosis yield inconsistent results.
  • Previous reviews on this association have been inconclusive.
  • Clarifying the evidence requires careful outcome classification and data synthesis.

Purpose of the Study:

  • To synthesize current evidence on the association between hepatitis C virus infection and coronary atherosclerosis.
  • To clarify the relationship between chronic hepatitis C and the risk and severity of coronary atherosclerosis.

Main Methods:

  • Systematic literature searches of PubMed and Scopus.
  • Identification and quality assessment of published observational studies.
  • Qualitative and quantitative syntheses, including meta-analyses, of 10 eligible studies.

Main Results:

  • Hepatitis C infection is associated with a threefold increased risk of coronary atherosclerosis (OR = 3.06).
  • Coronary atherosclerosis appears more severe in individuals with chronic hepatitis C.
  • The pooled risk of coronary atherosclerosis-related events in hepatitis C patients was not statistically significant (OR = 1.10).

Conclusions:

  • Hepatitis C virus or associated factors increase the risk and severity of coronary atherosclerosis.
  • The association between hepatitis C and coronary atherosclerosis-related events requires further investigation.
Abstract

Keywords:
Coronary artery diseaseHCVInflammationMeta-analysisMyocardial infarction

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