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The Emergence of Systematic Review in Toxicology
Martin L Stephens1, Kellyn Betts2, Nancy B Beck3
1Johns Hopkins Center for Alternatives to Animal Testing, Baltimore, Maryland msteph14@jhu.edu.
Summary
Systematic review methods are emerging in toxicology, drawing from medical approaches. Harmonizing these evidence-based methods across agencies is recommended for consistent application in toxicology.
Area of Science:
- Toxicology
- Evidence-based science
- Systematic review
Background:
- The Evidence-based Toxicology Collaboration convened a workshop on systematic review and evidence-based approaches in toxicology.
- The workshop gathered experts applying these methods in toxicology, from medicine and healthcare, and diverse stakeholders.
Framework:
- Examined historical antecedents of systematic review in medicine and toxicology.
- Identified challenges in translating medical systematic review methods to toxicology.
- Explored the current state of systematic review in toxicology.
Implementation:
- Focused on adapting systematic review methods for toxicological questions.
- Highlighted experiences from various agencies and organizations.
- Facilitated discussion among diverse stakeholders.
Implications:
- Recommends continued collaboration for harmonized application of systematic review methods.
- Aims to ensure consistency in evidence-based toxicology.
- Supports the advancement of reliable toxicological assessments.
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