Related Experiment Videos
[Use of the Sevac Immunoskintest kit in children]
Insights
The Immunoskintest SEVAC skin test evaluates cellular immunity in children. Healthy children and those with acute illnesses showed the highest immune response, while immunosuppressive therapy lowered it.
Area of Science:
- Immunology
- Pediatrics
- Cellular Immunity Assessment
Context:
- The Immunoskintest SEVAC is an antigen kit for skin testing.
- Assesses cellular immunity in pediatric populations.
- Evaluates immune status across various health conditions.
Purpose:
- To evaluate the state of cellular immunity in children using the Immunoskintest SEVAC.
- To establish reference values for skin test indices based on age and sex.
- To compare immune responses in children with different diseases and healthy controls.
Summary:
- 591 children (birth to 15 years) were tested, including those with CNS diseases, respiratory illnesses, tumors, hematological disorders, Mantoux II negative, and healthy children.
- Skin test values were correlated with age and sex.
- Lowest values were observed in children on immunosuppressive therapy; highest values were in healthy children and those with acute diseases. Boys exhibited higher values than girls.
- No undesirable side reactions were reported.
Impact:
- Provides insights into cellular immunity in pediatric patients with diverse medical conditions.
- Establishes normative data for Immunoskintest SEVAC in children.
- Highlights the utility of skin testing for immune status evaluation in pediatrics.
- Demonstrates the safety of the Immunoskintest SEVAC kit.
Abstract:
The Immunoskintest SEVAC is a kit of antigens for skin tests to evaluate the state of cellular immunity. By means of this kit 591 children from birth to 15 years were examined: the children suffered from acute diseases of the CNS, respiratory diseases incl. relapsing ones, a malignant tumour, haematological disease, and there were children who were Mantoux II negative and healthy children from children's homes. The value of the index of the skin test was referred to the child's age and sex; the lowest values were recorded in children with immunosuppressive therapy and the highest values of the skin test were found in healthy children and those with acute disease; boys had higher values than girls. In none of the children undesirable side-reaction were recorded after administration of the antigens.