Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.7K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

2.5K
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mannosylated hemagglutinin peptides bind cyanovirin-N independent of disulfide-bonds in complementary binding sites.

RSC advances·2022
Same author

Particle Radiation Side-Effects: Intestinal Microbiota Composition Shapes Interferon-γ-Induced Osteo-Immunogenicity.

Radiation research·2022
Same author

Cyanovirin-N Binds Viral Envelope Proteins at the Low-Affinity Carbohydrate Binding Site without Direct Virus Neutralization Ability.

Molecules (Basel, Switzerland)·2021
Same author

Intestinal bacterial indicator phylotypes associate with impaired DNA double-stranded break sensors but augmented skeletal bone micro-structure.

Carcinogenesis·2019
Same author

A novel probiotic, Lactobacillus johnsonii 456, resists acid and can persist in the human gut beyond the initial ingestion period.

Gut microbes·2018
Same author

Retraction Note to: Mouse models of intestinal inflammation and cancer.

Archives of toxicology·2018

Related Experiment Video

Updated: Mar 20, 2026

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

2.1K

Mouse models for radiation-induced cancers.

Leena Rivina1, Michael J Davoren2, Robert H Schiestl

  • 1Department of Environmental Health Sciences.

Mutagenesis
|May 23, 2016
PubMed
Summary

Radiation exposure increases cancer risk. This study reviews mouse models (Mus musculus) to understand radiation-induced cancers like leukemia and lymphoma, aiding in developing mitigation treatments.

Area of Science:

  • Oncology
  • Radiation Biology
  • Genetics

Background:

  • Ionizing radiation exposure, accidental or therapeutic, elevates cancer risk.
  • Long-term effects of radiation exposure include mutations and precancerous cell replication.
  • Developing mitigation treatments requires understanding radiation-induced carcinogenesis.

Purpose of the Study:

  • To review inbred mouse models (Mus musculus) for studying radiation-induced cancers.
  • To describe methods of cancer induction and molecular pathologies in these models.
  • To identify suitable animal models for preclinical research on radiation exposure consequences.

Main Methods:

  • Review of relevant inbred and F1 hybrid Mus musculus strains.
  • Description of cancer induction methods (e.g., single whole-body dose, fractionated doses).

More Related Videos

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

10.2K
Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy
05:05

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Published on: November 29, 2018

11.8K

Related Experiment Videos

Last Updated: Mar 20, 2026

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

2.1K
PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

10.2K
Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy
05:05

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Published on: November 29, 2018

11.8K
  • Analysis of associated molecular pathologies for radiation-induced myeloid leukemia, thymic lymphoma, breast, and lung cancers.

    • Main Results:

    • Mus musculus strains are valuable for radiation cancer research due to physiological similarities with humans.
    • Specific mouse models are suitable for investigating radiation-induced myeloid leukemia, thymic lymphoma, breast, and lung cancers.
    • Detailed methods and molecular pathways for cancer induction are presented for each model.

    Conclusions:

    • Well-understood mouse models are essential for accurately recapitulating radiation-induced carcinogenesis.
    • This review provides a resource for selecting appropriate Mus musculus models for radiation oncology research.
    • Understanding these models can facilitate the development of novel therapeutic agents to mitigate radiation-induced cancer risk.