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[Hepatitis C during pregnancy, vertical transmission and new treatment possibilities]

José Antonio Muñoz-Gámez1, Javier Salmerón2, Ángeles Ruiz-Extremera3

  • 1Unidad de Apoyo a la Investigación, Complejo Hospitalario Universitario de Granada e Instituto Biosanitario de Granada, ibs.GRANADA, Granada, España.

Medicina Clinica
|May 23, 2016
PubMed

Insights

Hepatitis C virus (HCV) infection in pregnant women is common, with vertical transmission posing a risk to infants. New antiviral treatments offer hope for managing HCV during pregnancy.

Area of Science:

  • Hepatology
  • Virology
  • Maternal-Fetal Medicine

Background:

  • Hepatitis C virus (HCV) infection is a global health concern, leading to cirrhosis and liver cancer.
  • HCV prevalence in pregnant women mirrors the general population, without impacting pregnancy outcomes.
  • Vertical transmission (HCV-VT) is the primary infection route for children in developed nations.

Purpose of the Study:

  • To review HCV infection during pregnancy.
  • To identify risk factors for HCV vertical transmission.
  • To discuss diagnostic methods, monitoring, and novel treatments.

Main Methods:

  • Literature review of HCV infection in pregnancy.
  • Analysis of risk factors for mother-to-child transmission.
  • Evaluation of diagnostic and monitoring strategies.
  • Assessment of direct-acting antiviral agents for HCV treatment.

Main Results:

  • HCV-VT occurs in 3-8% of cases, increasing to 15-20% with HIV co-infection.
  • Pregnancy course is generally unaffected by HCV.
  • Direct-acting antivirals represent a significant advancement in HCV management.

Conclusions:

  • Understanding HCV infection in pregnancy is crucial for public health.
  • Risk stratification and timely treatment are essential for preventing HCV-VT.
  • Direct-acting antiviral agents offer new therapeutic avenues for pregnant women.

Keywords:
Antivirales de acción directaDirect-acting antiviral agentsFactores de riesgoGestaciónHepatitis C virusPregnancyRisk factorsTransmisión verticalVertical transmissionVirus de la hepatitis C

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