Related Experiment Video
Updated: Mar 20, 2026

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
[Chemotherapy and Anticancer Immune Responses]
1Dept. of Immunology, Shimane University Faculty of Medicine.
Abstract:
Chemotherapeutic agents are widely used for cancer treatment. However, conventional and maximum-tolerated dose chemotherapy is often associated with the risk of immune deterioration via the induction and recruitment of immunosuppressive cells. Therefore, certain chemotherapeutic agents with immunostimulatory effects, including the induction of immunogenic cancer cell death and inhibition of immunosuppressive cells, must be useful. The combination of chemotherapy and immunotherapy is a promising new modality for the treatment of cancer patients. In this manuscript, I outline the in vivo induction of antitumor T cell immunity after chemotherapy and its underlying mechanisms and introduce immunogenic chemotherapy and several combinations of chemotherapy and immunotherapy.
More Related Videos
09:04Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
Related Concept Videos
Tumor Immunotherapy
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies