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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

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The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Updated: Mar 20, 2026

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

[Chemotherapy and Anticancer Immune Responses].

Mamoru Harada¹

¹Dept. of Immunology, Shimane University Faculty of Medicine.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|May 24, 2016

Summary

Certain chemotherapies can stimulate anti-tumor T cell immunity and inhibit immunosuppressive cells, offering a promising approach for cancer treatment when combined with immunotherapy.

Area of Science:

Oncology
Immunology
Cancer Research

Context:

Conventional chemotherapy can suppress the immune system.
Chemotherapy can induce immunosuppressive cells, hindering anti-tumor responses.
There is a need for cancer treatments that enhance, rather than suppress, anti-tumor immunity.

Purpose:

To explore chemotherapeutic agents with immunostimulatory effects.
To investigate the mechanisms of chemotherapy-induced anti-tumor T cell immunity.
To introduce the concept of immunogenic chemotherapy and its combination with immunotherapy.

Summary:

Chemotherapy can be harnessed to induce immunogenic cancer cell death and inhibit immunosuppressive cells.
This approach stimulates in vivo anti-tumor T cell immunity.

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Combining chemotherapy with immunotherapy presents a promising strategy for cancer treatment.

Impact:

Highlights the potential of specific chemotherapeutic agents to enhance anti-tumor immunity.
Provides a framework for developing novel combination therapies for cancer.
Suggests a paradigm shift from solely cytotoxic chemotherapy to immune-stimulating strategies.