Choroid plexus hemangioma with glial nodules in a premature stillborn study

An unruptured hemangioma (vascular malformation) of the choroid plexus of the lateral ventricle in a premature stillborn baby is described. Along the flattened choroid plexus epithelium covering the hemangioma there were small, discrete glial nodules which stained strongly and diffusely for glial fibrillary acidic protein (GFAP). The glial nodules were devoid of surface epithelium and confined within the basement membrane region of the choroid plexus epithelium. GFAP positive cells were not present elsewhere in the choroid plexus. The histogenesis of the glial nodules, whether they have resulted from glial differentiation of reactive choroid plexus epithelium or represented glial heterotopia, remains uncertain.