[Rare side effects in management of hyperthyroidism. Case report]

Area of Science:

• Endocrinology
• Nephrology
• Rheumatology

Background:

• Hyperthyroidism management involves antithyroid drugs with potential serious side effects.
• Propylthiouracil and thiamasol are common antithyroid medications.
• Rare but severe adverse drug reactions necessitate careful patient monitoring.

Observation:

• A patient with hyperthyroidism developed propylthiouracil-induced vasculitis with renal involvement.
• The patient subsequently experienced agranulocytosis with fever after treatment with thiamasol.
• Lithium carbonate provided temporary management before thyroidectomy.

Findings:

• Withdrawal of propylthiouracil and corticosteroid therapy led to complete recovery from vasculitis.
• Thiamasol treatment resulted in a severe adverse reaction (agranulocytosis).
• Thyroidectomy was successfully performed after managing drug-induced complications.

Implications:

• This case underscores the rare but significant risks associated with antithyroid drug therapy.
• Effective management of hyperthyroidism may require multidisciplinary approaches to address complex side effects.
• Highlights the importance of vigilant monitoring for adverse drug reactions in endocrine disorders.