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Deubiquitinases and cancer: A snapshot

Nishant Singh1, Anuradha Bharara Singh2

  • 1Department of Biological Sciences, Cleveland State University, Cleveland, OH 44115, USA.

Critical Reviews in Oncology/Hematology
|May 24, 2016
PubMed

Insights

Deubiquitinases (DUBs) regulate protein degradation and cellular processes. This review summarizes DUBs

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Ubiquitination controls protein degradation and cellular processes.
  • Deubiquitinases (DUBs) are key regulators of ubiquitination.
  • Dysregulation of DUBs is implicated in cancer and other diseases.

Purpose of the Study:

  • To review the process of deubiquitination.
  • To summarize the role of DUBs in cancer development.
  • To explore small molecule DUB inhibitors as potential cancer therapeutics.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of DUBs' enzymatic activity and regulatory functions.
  • Examination of preclinical and clinical studies on DUB inhibitors.

Main Results:

  • DUBs play critical roles in diverse cellular signaling pathways.
  • Aberrant DUB activity contributes to oncogenesis.
  • Several small molecule DUB inhibitors show promise in cancer treatment.

Conclusions:

  • Deubiquitination is a crucial regulatory mechanism.
  • Targeting DUBs offers a viable strategy for cancer therapy.
  • Further research into DUB inhibitors is warranted for drug development.
Keywords:
CancerDUBsDUBs inhibitorsDeubiquitinasesDeubiquitinationUbiquitination

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