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Biomarkers to identify and isolate senescent cells.

Mantas Matjusaitis1, Greg Chin2, Ethan Anders Sarnoski2

  • 1Scottish Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, England, UK.

Ageing Research Reviews
|May 24, 2016
PubMed
Summary

Cellular senescence, a key driver of aging and disease, involves cells with a senescence-associated secretory phenotype (SASP). Identifying these cells with reliable biomarkers is crucial for developing therapies to combat age-related decline.

Keywords:
AgingBiomarkersCell biologySenescence

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Area of Science:

  • Gerontology and Cellular Biology
  • Biomarker Discovery
  • Molecular Medicine

Background:

  • Cellular senescence contributes to age-related tissue dysfunction and diseases via the senescence-associated secretory phenotype (SASP).
  • The SASP negatively impacts neighboring cells, promoting aging, tumor development, and diseases like atherosclerosis and neurodegeneration.
  • Removing senescent cells shows potential for delaying age-related degeneration and extending lifespan.

Purpose of the Study:

  • To review and discuss biomarkers for identifying senescent cells.
  • To explore technologies and markers suitable for isolating senescent cells in vitro and in vivo.
  • To highlight the necessity of reliable biomarkers for understanding cell aging and enabling senescent cell removal therapies.

Main Methods:

  • Review of existing literature on cellular senescence and biomarkers.
  • Discussion of various biomarker classes and their applications.
  • Analysis of technologies for identifying and isolating senescent cells.

Main Results:

  • Senescent cells share common characteristics enabling identification, but a single universal biomarker may be challenging.
  • Various biomarkers exist, each with specific utilities for detecting senescent cells.
  • Technologies for identifying and isolating senescent cells are evolving.

Conclusions:

  • Reliable identification of senescent cells is essential for advancing research into aging and age-related diseases.
  • Biomarker development is critical for therapeutic strategies targeting senescent cells.
  • A multifaceted approach to biomarker selection may be necessary due to cell-type variability.