Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial lesion in hypertension.

J Hladovec1, I Prerovský

  • 1Cardiovascular Research Programme, Institute of Clinical and Experimental Medicine, Prague, Czechoslovakia.

Cor Et Vasa
|January 1, 1989
PubMed
Summary

Hypertension may cause latent endothelial lesions, indicated by a higher count of circulating endothelial cells after a methionine challenge in hypertensive patients compared to healthy individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Homocysteinemia and endothelial damage after methionine load.

Thrombosis research·1998
Same author

Lack of evidence for the interaction between renin-angiotensin-aldosterone system and endothelin in vivo.

Physiological research·1996
Same author

[The antiphospholipid syndrome and atherothrombosis].

Casopis lekaru ceskych·1995
Same author

[Lipoperoxides and their clinical importance].

Casopis lekaru ceskych·1995
Same author

Homocysteine theory of atherosclerosis.

Sbornik lekarsky·1995
Same author

[Heparan sulfate and its function in the endothelium].

Casopis lekaru ceskych·1994

Area of Science:

  • Cardiovascular Research
  • Endothelial Biology
  • Hypertension Studies

Background:

  • Endothelial dysfunction is an early indicator of cardiovascular disease.
  • Hypertension is a major risk factor for endothelial damage.
  • Assessing endothelial health is crucial for predicting cardiovascular events.

Purpose of the Study:

  • To investigate the utility of circulating endothelial cell (CEC) counts following a methionine challenge as a biomarker for latent endothelial lesions in hypertensive individuals.
  • To compare CEC counts between hypertensive patients and healthy controls.

Main Methods:

  • A methionine challenge test was administered to both hypertensive and healthy control groups.
  • Circulating endothelial cell (CEC) counts were measured before and after the methionine challenge.
  • Statistical analysis was performed to compare CEC counts between the groups.

Main Results:

  • Hypertensive individuals exhibited a significantly higher circulating endothelial cell (CEC) count post-methionine challenge compared to healthy controls.
  • The methionine challenge effectively differentiated between the two groups based on CEC levels.

Conclusions:

  • Elevated CEC counts after methionine challenge suggest the presence of latent endothelial lesions in hypertension.
  • This method shows potential as a non-invasive diagnostic tool for early endothelial damage in hypertensive patients.
  • Further research is warranted to validate this method in larger, diverse populations.

Related Experiment Videos