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Related Experiment Videos

Physiological consequences of human skin aging.

A K Balin1, L A Pratt

  • 1Laboratory for Investigative Dermatology, Rockefeller University, New York, New York 10021.

Cutis
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

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Aging skin undergoes significant anatomical and physiological changes, affecting disease susceptibility and treatment in older adults. Understanding these intrinsic aging processes is crucial for effective dermatological care in the elderly.

Area of Science:

  • Dermatology
  • Gerontology
  • Aging Research

Background:

  • Aging skin exhibits distinct anatomical and physiological alterations compared to younger skin.
  • These changes impact disease presentation, susceptibility, and treatment efficacy in elderly patients.

Purpose of the Study:

  • To summarize the major intrinsic aging processes of the skin.
  • To aid in the recognition and treatment of cutaneous diseases in older individuals.

Main Methods:

  • Review of anatomical and physiological changes associated with intrinsic skin aging.
  • Synthesis of data on altered epidermal renewal, immune function, and vascular supply.

Main Results:

  • Reduced epidermal renewal, tissue repair, and hair/nail growth.

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  • Decreased eccrine, apocrine, and sebum secretion.
  • Altered immune surveillance, antigen presentation, and cutaneous vascular supply, impacting inflammatory responses and clearance.

    • Conclusions:

    • Intrinsic aging significantly alters skin structure and function, influencing disease expression.
    • Recognition of these age-related changes is essential for optimizing dermatological care in the elderly.