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Dry powder inhalable formulations for anti-tubercular therapy
Thaigarajan Parumasivam1, Rachel Yoon Kyung Chang1, Sharif Abdelghany2
1Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia.
Advanced Drug Delivery Reviews
|May 24, 2016
Summary
Inhalable dry powder formulations offer a promising approach to tuberculosis treatment by delivering drugs directly to the lungs. This method enhances efficacy and reduces side effects compared to traditional therapies.
Area of Science:
- Pulmonary drug delivery
- Infectious disease therapeutics
- Pharmaceutical formulation science
Background:
- Tuberculosis (TB) treatment faces challenges due to prolonged therapy, multiple drugs, and side effects.
- Mycobacterium tuberculosis infection requires innovative therapeutic strategies.
- Pulmonary drug delivery offers a targeted, non-invasive route for TB treatment and vaccination.
Purpose of the Study:
- To review innovations in inhalable dry powder formulations for tuberculosis (TB) drug and vaccine delivery.
- To examine powder production methods, preclinical, and clinical evaluations over the last decade.
- To address the risks associated with pulmonary TB therapy.
Main Methods:
- Review of recent literature on dry powder inhaler technology for TB.
- Analysis of powder production techniques and formulation characteristics.
- Evaluation of preclinical and clinical data for inhaled TB therapies.
Main Results:
- Dry powder formulations are stable, require no refrigeration, and are suitable for high-dose delivery via inhalers.
- Inhaled delivery targets the lungs, potentially reducing drug dosage and systemic side effects.
- Recent innovations focus on respirable particles and cost-effective inhaler devices.
Conclusions:
- Inhalable dry powder formulations represent a significant advancement in TB drug and vaccine delivery.
- Optimized formulations and devices can improve treatment adherence and outcomes.
- Pulmonary delivery offers a viable strategy to overcome challenges in TB management.
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