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Updated: Mar 20, 2026
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Prognostic value of FOXA1 in breast cancer: A systematic review and meta-analysis
Jiafeng Shou1, Yucheng Lai1, Jinming Xu1
1Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 31009, China.
Background:
Despite some published papers analyzing the prognostic role of forkhead-box A1 (FOXA1) in breast cancer, it has not yet been considered as an established prognostic factor in clinical practice. The present meta-analysis evaluated the prognostic value of FOXA1 in breast cancer.
Methods:
PubMed, Web of Science and Embase databases were searched for relevant published literature that evaluated the correlation between FOXA1 and breast cancer. Either a fixed or random effect model was applied to estimate the pooled hazard ratio (HR) for FOXA1 prognosis in breast cancer.
Result:
A total of nine articles comprising 6386 breast cancer patients met the inclusion criteria. Among these nine studies, five studies and four studies investigated the prognostic association with disease-free survival (DFS), and overall survival (OS), respectively. Meta-analysis results suggested that high FOXA1 expression was positively associated with DFS (pooled HR: 0.43, 95% CI: 0.23-0.81; P < 0.05) and OS (pooled HR: 0.39, 95% CI: 0.26-0.60; P < 0.05) in breast cancer patients. No publication bias was discovered by Begg's test in this meta-analysis.
Conclusion:
The results from this meta-analysis indicated that elevated FOXA1 expression level was associated with better outcome in breast cancer.
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