Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study
Felix Kaspar1, Herbert F Jelinek2, Steven Perkins3
1Department of Biotechnology, Institute for Biochemistry and Biotechnology, Technical University Braunschweig, 38126 Braunschweig, Germany; School of Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
Objective:
This study compared acute and late effect of single-bout endurance training (ET) and high-intensity interval training (HIIT) on the plasma levels of four inflammatory cytokines and C-reactive protein and insulin-like growth factor 1.
Design:
Cohort study with repeated-measures design.
Methods:
Seven healthy untrained volunteers completed a single bout of ET and HIIT on a cycle ergometer. ET and HIIT sessions were held in random order and at least 7 days apart. Blood was drawn before the interventions and 30 min and 2 days after the training sessions. Plasma samples were analyzed with ELISA for the interleukins (IL), IL-1β, IL-6, and IL-10, monocyte chemoattractant protein-1 (MCP-1), insulin growth factor 1 (IGF-1), and C-reactive protein (CRP). Statistical analysis was with Wilcoxon signed-rank tests.
Results:
ET led to both a significant acute and long-term inflammatory response with a significant decrease at 30 minutes after exercise in the IL-6/IL-10 ratio (-20%; p = 0.047) and a decrease of MCP-1 (-17.9%; p = 0.03).
Conclusion:
This study demonstrates that ET affects the inflammatory response more adversely at 30 minutes after exercise compared to HIIT. However, this is compensated by a significant decrease in MCP-1 at two days associated with a reduced risk of atherosclerosis.
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