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Penetration of monobactam antibiotics (aztreonam, carumonam) into human prostatic tissue
M Whitby1, J Hempenstall, C Gilpin
1Department of Infectious Diseases, Princess Alexandra Hospital, Brisbane, Australia.
Chemotherapy
|January 1, 1989
Abstract:
Concomitant concentrations of monobactam antibiotics were measured in plasma and in prostatic tissue obtained by transurethral resection in 25 patients, 60-120 min after dosage. A 1-gram single intravenous injection of aztreonam or carumonam yielded mean prostatic concentrations of 6.0 mg/kg in 20 patients. Five patients who received a 2-gram dose of carumonam demonstrated average prostatic levels of 10 mg/kg. These concentrations significantly exceed MIC values for most common gram-negative urinary tract pathogens.