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Related Experiment Video

Updated: Mar 20, 2026

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Moxibustion upregulates hippocampal progranulin expression.

Tao Yi1, Li Qi2, Ji Li1

  • 1Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; College of Integrated Traditional Chinese and Western Medicine, Fudan University, Shanghai, China.

Neural Regeneration Research
|May 24, 2016
PubMed
Summary

Moxibustion treatment may alleviate chronic fatigue syndrome symptoms in rats by regulating the stress response and increasing progranulin in the hippocampus. This traditional therapy offers a potential mechanism for managing stress-related fatigue.

Keywords:
adrenocorticotropic hormonebehavioral symptomschronic fatigue syndromecorticosteronecorticotrophin-releasing hormonehippocampushypothalamic-pituitary-adrenal axismoxibustionnerve regenerationneural regenerationprogranulintraditional Chinese medicine

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Area of Science:

  • Neuroscience
  • Integrative Medicine
  • Stress Physiology

Background:

  • Chronic fatigue syndrome (CFS) is increasingly linked to stress and hypothalamic-pituitary-adrenal (HPA) axis dysregulation.
  • Moxibustion, a traditional Chinese therapy, shows promise for CFS but its underlying mechanisms remain unclear.
  • Understanding how moxibustion impacts the HPA axis and related neurobiological factors is crucial for its clinical application.

Purpose of the Study:

  • To investigate the effects of moxibustion on behavioral symptoms of CFS in a rat model.
  • To explore the potential mechanisms by which moxibustion influences the HPA axis and hippocampal progranulin expression.
  • To provide scientific evidence for the efficacy and mechanisms of moxibustion in managing CFS.

Main Methods:

  • A rat model of CFS was established using chronic restraint stress and forced swimming.
  • Moxibustion was applied to the Guanyuan (CV4) and Zusanli (ST36) acupoints.
  • Behavioral tests (forced swimming, open field, tail suspension), real-time PCR, ELISA, and Western blot were used to assess outcomes.

Main Results:

  • Moxibustion treatment significantly reduced depressive and anxiety-like behaviors in CFS rats.
  • Moxibustion decreased hypothalamic corticotropin-releasing hormone mRNA expression.
  • Moxibustion lowered plasma adrenocorticotropic hormone and corticosterone levels, while increasing hippocampal progranulin mRNA and protein expression.

Conclusions:

  • Moxibustion may effectively alleviate behavioral symptoms associated with chronic fatigue syndrome in rats.
  • The therapeutic effects of moxibustion appear to involve the modulation of the HPA axis.
  • Upregulation of hippocampal progranulin by moxibustion represents a key mechanism in its anti-fatigue effects.