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Benign metastasizing leiomyomas in the lungs: a case study.
Alina Janina Wiencek-Weiss1, Krzysztof Bruliński1
1Center of Pulmonology and Thoracic Surgery, Bystra, Poland.
Summary
Benign metastasizing leiomyoma (BML) is a rare lung condition in women with a history of uterine fibroids. This case highlights hormonal therapy
Area of Science:
- Gynecologic Oncology
- Pulmonary Medicine
- Endocrinology
Background:
- Benign metastasizing leiomyoma (BML) is a rare neoplastic proliferation.
- It typically affects women of reproductive age with a history of uterine leiomyomas.
- Pulmonary BML is the most common extrapelvic site.
Observation:
- A 44-year-old obese woman with a history of uterine leiomyomata presented with multiple pulmonary nodules.
- The patient had a 15-year history of estradiol hormone therapy.
- Computed tomography revealed bilateral lung nodules of varying sizes.
Findings:
- Surgical resection and histopathology confirmed benign metastasizing leiomyoma.
- Tumor cells stained positive for estrogen and progesterone receptors (ER+, PR+).
- Hormonal therapy was discontinued due to hormone-dependent proliferation.
Implications:
- This case underscores the importance of considering hormonal influences in BML management.
- Treatment with a gonadotropin-releasing hormone analog led to radiological stabilization.
- Further research into targeted hormonal therapies for BML is warranted.
