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Micronodular cirrhosis after thiabendazole.

M A Roy¹, F W Nugent, H T Aretz

¹Department of Gastroenterology, Lahey Clinic Medical Center, Burlington, Massachusetts 01805.

Digestive Diseases and Sciences

|June 1, 1989

Summary

Thiabendazole-induced liver injury is rare but can lead to severe cholestasis. This case highlights a rare progression to micronodular cirrhosis, emphasizing the need for monitoring drug-induced hepatotoxicity.

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Area of Science:

Hepatology
Pharmacology
Toxicology

Background:

Thiabendazole, an antiparasitic agent, has been associated with rare instances of hepatotoxicity since its introduction in 1964.
Most reported cases of thiabendazole-induced intrahepatic cholestasis resolve spontaneously within months.

Observation:

A review of existing literature identified 15 cases of thiabendazole-induced hepatotoxicity, with 14 showing resolution of cholestasis.
One prior report documented the progression of cholestasis to cirrhosis in a patient treated with thiabendazole.

Findings:

This report details a second case of intrahepatic cholestasis following thiabendazole treatment.
The observed cholestasis progressed to severe micronodular cirrhosis, a rare and severe outcome.

Implications:

This case underscores the potential for severe, progressive liver damage from thiabendazole, even if rare.
Clinicians should consider monitoring liver function in patients receiving thiabendazole, particularly those with prolonged treatment or risk factors.

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