Related Experiment Video
Updated: Mar 20, 2026

In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
Published on: November 28, 2017
Do vaccinations affect the clinical course of systemic necrotising vasculitis? A prospective observational web-based
Solen Kernéis1, Clément Turbelin2, Christian Pagnoux3
1Univ. Paris-Descartes, Sorbonne Paris Cité, Médecine; Assistance Publique-Hôpitaux de Paris, Dept. of Infectious Diseases, Hôpital Cochin; Inserm CIC 1417; Sorbonne Univ., UPMC Univ. Paris 06, Inst.Pierre-Louis d'Épidémiologie-Santé Publ., Paris, France.
Objectives:
To estimate the impact of vaccinations, infections and traumatic life events on the disease activity of a web-based cohort of systemic necrotising vasculitis (SNV) patients.
Methods:
Adults diagnosed with SNV self-reported vaccinations, infectious episodes and traumatic life events every 3 months during follow-up on a secure dedicated website. Participants reported information on disease activity assessed with 3 scores: the French version of the Medical Outcome Study Short Form-36 (SF-36), the visual numerical scale for Patient Global Assessment (PGA) and the modified Disease Extent Index (mDEI).
Results:
Between December 2005 and October 2008, 145 participants (mean ± SD age 53±13 years; 57% males) were included. Mean follow-up was 445±325 days. SNVs were distributed as follows: 46% granulomatosis with polyangiitis (Wegener's), 22% eosinophilic granulomatosis with polyangiitis (Churg-Strauss), 18% polyarteritis nodosa and 8% microscopic polyangiitis. During follow-up, 94 vaccinations, 57 acute infectious episodes and 274 traumatic life events were reported. In univariate and multivariate analyses, only traumatic life events were significantly associated with decreased SF-36 mental and physical component scores. No significant SF-36, PGA and mDEI scores variations were reported during the 3 months following acute infectious episode or vaccine administration.
Conclusions:
No significant clinical impact of vaccinations on SNV activity was found in this prospective observational study.
More Related Videos
Related Concept Videos
Vaccinations
Acute Pyelonephritis II: Diagnostic Studies and Management
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Endocarditis II: Clinical Features of Infective Endocarditis
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Endocarditis I: Introduction

