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Updated: Mar 20, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
Inherited combined deficiency of factors XI and XII with von Willebrand's disease
M D Čolović1, P Miljić1, R B Čolović1
1Institute of Hematology, University Clinical Center of Serbia, 11000 Beograd, ul.Koste Todorovica br 2, Yugoslavia.
Abstract:
Combined hereditary deficiency of factors XI (FXI) and XII (FXII) associated with the deficeincy of von Willebrand factor (vWF) in a single patient has not been reported so far in the literature. We report on two brothers of non-Jewish stock with defciency of FXI, FXII and vWF. The family studies disclosed FXI and FXII deficiency in the mother of propositi. A maternal niece had FXII deficiency. The father of propositi had vWF deficiency. This study suggests possible existence of a regulatory factor common to genes specifying FXI and FXII. Associated vWF deficiency is coincidental.
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